2023 Rising Stars in Reproductive Biology Webinar Series

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2023 Rising Stars in Reproductive Biology Webinar Series


The Rising Stars in Reproductive Biology series is designed to introduce and highlight research from new investigators to the SSR membership and broader reproductive biology research community.

Each presentation will feature a 1-2 min introduction by an invited moderator, a 20 min talk by each Rising Star speaker, and 5-7 min for questions and answers.


Rising Stars- February 8, 2023
12-1pm ET

Program:

Storing Sugar in the Uterus: Glycogen Metabolism during Early Pregnancy
Speaker:
Matthew Dean, PhD

Opportunities for Innovation in microTESE Negative Males With Non-Obstructive Azoospermia
Speaker: Ryan Flannigan, PhD

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Speakers:

Dr. Matthew Dean, Department of Animal Sciences, University of Illinois, Urbana-Champaign

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Read Dr. Dean's Bio

Dr. Dean is a reproductive physiologist interested in the function of the uterus, oviducts, and ovaries. His lab uses novel experimental models and the inherent differences among species to increase our understanding of the reproductive system. His goal is to solve problems important in human medicine and animal agriculture while also providing an environment that prepares trainees for the next step in their careers.

Dr. Dean has won national awards from the Society for the Study of Reproduction and The Endocrine Society for his research. His work has been highlighted at EurekAlert! and Chemical & Engineering News.

Read more about Dr. Dean's Presentation

Title: Storing Sugar in the Uterus: Glycogen Metabolism during Early Pregnancy

The endometrium needs to regulate glucose availability precisely; too much or too little impairs decidualization and embryo development. We have shown that the epithelium and decidua store distinct pools of glucose as glycogen during early pregnancy. Thus, glycogen may represent a vital way to buffer glucose concentrations before and during implantation.



Dr. Ryan Flannigan, Department Of Urologic Sciences, University Of British Columbia


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Read Dr. Flannigan's Bio

Dr. Ryan Flannigan is a sub specialized reproductive microsurgeon and has dedicated his career to advancing his microsurgical skillset to optimize success rates for Vasectomy Reversals and microsurgical sperm retrievals.

Dr. Flannigan completed his fellowship training in Male Reproduction, Microsurgery at the world-renowned Weill Cornell Medicine and Memorial Sloan Kettering Center in New York, NY.

Dr. Flannigan now serves as the director of Male Reproduction and Sexual Medicine at the University of British Columbia, Senior surgeon-scientist within the UBC Department of Urologic Sciences, and Fellowship Director for Male Reproduction, Sexual Medicine and Microsurgery Training Program.

Dr. Flannigan is a surgeon scientist and has successfully competed for millions of dollars in research funding where he is investigating novel treatment approaches for infertile men. His research has contributed to nearly 200 publications including papers, book chapters and scientific abstracts.

Read more about Dr. Flannigan's Presentation

Title: Opportunities for Innovation in microTESE Negative Males With Non-Obstructive Azoospermia

This talk will discuss the opportunities for innovation in microTESE negative non-obstructive azoospermic males. We will discuss opportunities for applying image-based machine learning for sperm identification following microTESE. We will also discuss a personalized and precision medicine framework aiming to overcome cellular dysfunction and promote regeneration of spermatogenesis using single cell sequencing, development of novel culture methods, use of human induced pluripotent stem cells and 3D bioprinting.


Rising Stars- January 11, 2023

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Program:

Illuminating the (uterine) path: from embryo movement to implantation
Although much is known about the molecular signaling during implantation, the uterine 3D architecture that facilitates embryo development remains unknown. Imaging the mouse embryo and the uterine milieu simultaneously we uncovered patterns of embryo movement and dynamic shape changes in the uterine lumen and glands in preparation for implantation. When applied to mouse mutants with known implantation defects, this method detected striking peri-implantation abnormalities in uterine morphology that cannot be visualized by histology. Analyzing the uterine and embryo structure in 3D for genetic mutants, hormonal perturbations and pregnancies treated with pathway inhibitors is helping us uncover novel molecular pathways and global structural changes that contribute to successful implantation of an embryo. Our studies have implications for understanding how structure-based embryo-uterine communication is key to determining an optimal implantation site, which is necessary for the success of a pregnancy.

Speaker: Dr. Ripla Arora, Assistant Professor, Department of Obstetrics, Michigan State University

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Ripla Arora is an assistant professor in the Department of Obstetrics, Gynecology, and Reproductive Biology and the Institute for Quantitative Health Science and Engineering at Michigan State University. Dr. Arora received her PhD degree in Genetics and Development from Columbia University where she studied the role of T-box transcription factors in umbilical vessel and lung development. As a post-doctoral fellow at the University of California, San Francisco she developed a novel 3D imaging and quantitative modeling method for uterine biology. Her lab research focuses on uncovering novel 3D structure based mechanisms that guide early embryo-uterine interactions for implantation and uterine developmental biology. Dr. Arora has been awarded the March of Dimes Basil O'Connor Starter Scholar Research Award, the Jean Schultz Biomedical Research Award from MSU, an NIH R01 grant as principal investigator and six NIH R01 grants as co-investigator.

Sex-differences in immune aging: are we missing half of the picture?
Neutrophils are the most abundant human white blood cell and constitute a first line of defense in the innate immune response. Neutrophils are short-lived cells, and thus the impact of organismal aging on neutrophil biology, especially as a function of biological sex, remains poorly understood. We have generated a multi-omic resource of mouse primary bone marrow neutrophil from young and old female and male mice, at the transcriptomic, metabolomic and lipidomic levels. We identified widespread regulation of neutrophil ‘omics’ landscapes with organismal aging and biological sex. In addition, we leveraged this data to predict functional differences, including changes in neutrophil responses to activation signals. To date, this dataset represents the largest multi-omics resource for neutrophils across sex and ages. This resource identifies neutrophil characteristics which could be targeted to improve immune responses as a function of sex and/or age.

Speaker: Dr. Bérénice Benayoun, Assistant Professor of Gerontology, USC

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Bérénice Benayoun, Ph.D., is an Assistant Professor of Gerontology at the USC Leonard Davis School of Gerontology. Benayoun’s PhD work focused on a transcription factor whose mutations lead to a human syndrome associated to premature menopause. During her post-doctoral training, she identified a chromatin signature of cell identity remodeled with aging, raising questions about the lifelong stability of cellular identity. Her lab’s research focuses on age-related ‘omic’ changes, and how they interact with sex to shape aging. Her lab is also pioneering the naturally short-lived African turquoise killifish Nothobranchius furzeri as a new vertebrate model for aging research.




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